使用异体I型胶原治疗烧伤和供体部位

E. A. Zhirkova, A. Sachkov, T. G. Spiridonova, N. Borovkova, A. O. Medvedev, N. E. Pidchenko, M. A. Migunov, S. V. Frolov, M. E. Makarova, O. V. Troshina, I. N. Ponomarev, A. Mironov, M. M. Nikolayeva
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摘要

介绍。寻找减少供体部位烧伤和伤口治疗时间的方法目前仍具有重要意义。本回顾性研究的目的是评价异体I型胶原敷料局部治疗II-IIIA度烧伤和供区创面的效果。材料和方法。该研究包括2018-2021年住院的434名患者。280例患者使用胶原蛋白敷料(II-IIIA度烧伤234例,供区创面46例);对照组154例患者按烧伤护理标准进行传统治疗。患者在年龄和烧伤面积(全身、浅表、深部)方面无统计学差异。基于I型胶原蛋白的冻干无菌敷料。FSR 2009/06370(2014年12月8日)按照TU号9393-002-01967081-2008由我所组织保存和移植物制造部生产。我们比较了使用胶原敷料与常规治疗时伤口上皮化的时间,以及用视觉模拟疼痛量表评估供体部位的疼痛强度。II-IIIA度烧伤创面完全上皮化时间,使用胶原敷料为10(7;12)天,不使用胶原敷料为18(14;20)天,差异有统计学意义(p<0.001)。胶原敷料组创面上皮化时间为9(8;10)天,常规治疗组创面上皮化时间为11(10;12)天(p<0.001)。用视觉模拟量表评估胶原蛋白应用后供区创面疼痛强度在第1、4、7天均明显低于常规治疗组(p<0.001, p<0.001, p=0.003)。使用基于I型异体胶原的敷料治疗浅表烧伤和供区,减少了再上皮化的时间,减轻了供区伤口的疼痛强度,证明了这种治疗方法更有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Burns and donor site treatment using allogeneic type I collagen
Introduction. The search for methods to reduce the time of treatment of burns and wounds of the donor sites currently remains relevant.Aim. Objective of this retrospective study was to evaluate the effectiveness of local treatment of II–IIIA degree burns and donor site wounds with dressings based on allogeneic type I collagen.Material and methods. The study included 434 patients hospitalized in 2018–2021. Collagen dressings were used in 280 patients (234 with II–IIIA degree burns and 46 with donor site wounds); 154 patients of the comparison group received traditional treatment in accordance with the standards of care for burns. Patients did not differ statistically significantly in age and the area of burns (general, superficial, deep). Lyophilized, sterile dressings based on type I collagen (RC No. FSR 2009/06370 December 8, 2014) were manufactured in accordance with TU No. 9393-002-01967081-2008 by the Department for Tissue Preservation and Graft Manufacturing of our Institute. We compared the timing of wound epithelialization when using collagen dressings versus the conventional treatment, and the pain intensity in the donor sites as assessed by the visual analogue scale for pain.Results. The terms of complete epithelialization of II–IIIA degree burn wounds made 10 (7;12) days when collagenbased dressings were used, and 18 (14;20) days without collagen, the difference being statistically significant (p<0.001). Epithelialization of the donor site wounds took 9 (8;10) days with using collagen dressings, and 11 (10;12) days with conventional treatment (p<0.001). The visual analogue scale assessed pain intensity in the donor site wounds after collagen application was statistically significantly lower on days 1, 4, and 7 than in patients on conventional treatment (p<0.001, p<0.001, p=0.003, respectively).Conclusion. The use of dressings based on type I allogeneic collagen for the treatment of superficial burns and the donor sites reduces the time of re-epithelialization, decreases the pain intensity in the donor site wounds, which proves the greater efficacy of this treatment method.
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