A. C. Felix, A. Gastaldi, S. G. Dutra, Ana Caroline Silva de Freitas, S. V. Philbois, Tábata de Paula Facioli, V. J. D. da Silva, T. H. Fares, H. C. D. de Souza
{"title":"早期卵巢激素剥夺增加老年雌性大鼠心脏收缩力——体育锻炼的作用","authors":"A. C. Felix, A. Gastaldi, S. G. Dutra, Ana Caroline Silva de Freitas, S. V. Philbois, Tábata de Paula Facioli, V. J. D. da Silva, T. H. Fares, H. C. D. de Souza","doi":"10.1249/01.mss.0000561508.53212.ea","DOIUrl":null,"url":null,"abstract":"OBJECTIVES\nWe investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats.\n\n\nMETHODS\nFemale Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression quantification.\n\n\nRESULTS\nEchocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg). Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction in this response. While, β-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased expression of these receptors.\n\n\nCONCLUSION\nEarly ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases β-adrenergic receptors expression, influencing the cardiac contractility.","PeriodicalId":8666,"journal":{"name":"Autonomic Neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Early ovarian hormone deprivation increases cardiac contractility in old female rats—Role of physical training\",\"authors\":\"A. C. Felix, A. Gastaldi, S. G. Dutra, Ana Caroline Silva de Freitas, S. V. Philbois, Tábata de Paula Facioli, V. J. D. da Silva, T. H. Fares, H. C. D. de Souza\",\"doi\":\"10.1249/01.mss.0000561508.53212.ea\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"OBJECTIVES\\nWe investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats.\\n\\n\\nMETHODS\\nFemale Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression quantification.\\n\\n\\nRESULTS\\nEchocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg). Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction in this response. While, β-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased expression of these receptors.\\n\\n\\nCONCLUSION\\nEarly ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases β-adrenergic receptors expression, influencing the cardiac contractility.\",\"PeriodicalId\":8666,\"journal\":{\"name\":\"Autonomic Neuroscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autonomic Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1249/01.mss.0000561508.53212.ea\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1249/01.mss.0000561508.53212.ea","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Early ovarian hormone deprivation increases cardiac contractility in old female rats—Role of physical training
OBJECTIVES
We investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats.
METHODS
Female Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression quantification.
RESULTS
Echocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg). Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction in this response. While, β-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased expression of these receptors.
CONCLUSION
Early ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases β-adrenergic receptors expression, influencing the cardiac contractility.