早期卵巢激素剥夺增加老年雌性大鼠心脏收缩力——体育锻炼的作用

A. C. Felix, A. Gastaldi, S. G. Dutra, Ana Caroline Silva de Freitas, S. V. Philbois, Tábata de Paula Facioli, V. J. D. da Silva, T. H. Fares, H. C. D. de Souza
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引用次数: 2

摘要

目的探讨早期卵巢激素剥夺对老年大鼠卵巢形态学和心功能的影响,以及有氧训练对这些指标的影响。方法雌性Wistar大鼠(N = 48)在10 周龄时分为两组:早期卵巢切除术(OVX)剥夺卵巢激素;N = 24)和sham (sham;N = 24)。在第62周至第82周,每组12只动物进行有氧训练(OVX-T和SHAM-T, N = 12)。在第82周结束时,通过超声心动图、心功能(Langendorff技术)和心脏β-肾上腺素能受体表达定量评估所有患者。结果OVX组和SHAM组心肌形态学变化不大。OVX组(Δ = 101 ±4.7  mmHg)显示高值极大左心室内的压力在多巴酚丁胺反应,相比,虚假的集团(Δ = 55 ±11.8  毫米汞柱)。OVX-T(Δ = 70 ±4.0  毫米汞柱)和SHAM-T(Δ = 22 ±6.6  mmHg)组显示这种反应的减少。而β-肾上腺素能受体的表达在未训练组之间没有差异,SHAM-T(0.23 ± 0.02 AU)和OVX-T(0.29 ± 0.01 AU)显示这些受体的表达减少。结论卵巢早期激素剥夺与衰老有关,可促进心脏形态的离散变化,增强心脏收缩力。有氧训练降低β-肾上腺素能受体的表达,影响心脏收缩力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early ovarian hormone deprivation increases cardiac contractility in old female rats—Role of physical training
OBJECTIVES We investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats. METHODS Female Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression quantification. RESULTS Echocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg). Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction in this response. While, β-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased expression of these receptors. CONCLUSION Early ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases β-adrenergic receptors expression, influencing the cardiac contractility.
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