促甲状腺激素释放激素受体在GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI:10.2218/gtopdb/f63/2023.1

A. Davenport, M. Gershengorn, R. Hills

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引用次数: 0

摘要

促甲状腺激素释放激素(TRH)受体(NC-IUPHAR[14]推荐的临时命名)被内源性三肽TRH (plu - his - pronh2)激活。TRH和TRH类似物不能区分TRH1和TRH2受体[29]。[3H]TRH(人、小鼠、大鼠)能够标记TRH1和TRH2受体，Kd值分别为13 nM和9 nM。含TRH类似物的环修饰l -组氨酸的合成和生物学研究已有报道[10]。

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Thyrotropin-releasing hormone receptors in GtoPdb v.2023.1

Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature as recommended by NC-IUPHAR [14]) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors [29]. [3H]TRH (human, mouse, rat) is able to label both TRH1 and TRH2 receptors with Kd values of 13 and 9 nM respectively. Synthesis and biology of ring-modified L-Histidine containing TRH analogues has been reported [23].

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IUPHAR/BPS Guide to Pharmacology CITE

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