Physiological, Biochemical and Neurochemical responses of Cirrhinus mrigala upon short term exposure to Cerium oxide

The current study was performed to ascertain the biochemical and physiological impact of cerium oxide (CeO 2 ) on freshwater fish Cirrhinus mrigala , which are widely consumed. Biochemical, neurochemical and physiological modifications were evaluated and LC 50 of CeO 2 was found to be 22 ppm, observed for 24 h. Further 1/10 th of the LC 50 concentration of CeO 2 (2.2 ppm) was used for short term investigation at 96 h. The results demonstrate an increase in physiological levels of serum lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT) compared to control groups. Studies revealed variations in oxidative stress markers with a significant reduction in the serum superoxide dismutase (SOD) and catalase (CAT) activities and an increase in malondialdehyde (MDA). The study reported the increase in brain glutamate concentrations indicating possible brain tissue damage. The above analysis highlights the potential toxicological impact of CeO 2 on freshwater fish and their ecosystem.