毛刺叶对d -半乳糖胺所致大鼠肝毒性的保护作用

Radhe Shyam Sharma, B. Tyagi, P. Chouhan
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引用次数: 1

摘要

植物作为药用化合物的天然来源已被利用了数千年。人类使用大量的植物和植物衍生产品来治疗和缓解各种身心疾病。这些植物被用于传统的中国,阿育吠陀,悉达,乌纳尼和藏药。《梨俱吠陀》、《雅尤尔吠陀》、《阿达瓦吠陀》、《查拉克·萨姆希塔》和《苏舒拉特·萨姆希塔》等古代文献也描述了用植物治疗各种健康问题。近年来,世界范围内对植物研究的关注有所增加,已经收集了大量证据,表明在各种传统系统中使用的药用植物具有巨大潜力。材料与方法:研究毛刺叶乙醇提取物对d -半乳糖胺致Wistar大鼠肝损伤的保护作用。d -半乳糖胺(270 mg/kg体重)在为期两周的试验第14天腹腔注射引起肝毒性。在整个试验期间,以200和400 mg/kg体重的剂量口服所研究植物的提取物。水飞蓟素(100 mg/kg体重)作为标准保肝药物口服。结果与讨论:组织学研究显示,400mg /kg CP可减轻d-GalN中毒大鼠肝细胞坏死。结果表明,毛刺叶乙醇提取物可降低d -半乳糖胺对大鼠的肝毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HEPATOPROTECTIVE ACTIVITY OF CNIDOSCOLUS PHYLLACANTHUS LEAVES AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN RATS
Introduction: Plants have been utilized as a natural source of medicinal compounds for thousands of years. Humans use numerous plants and plant-derived products to cure and relieve various physical and mental illnesses. These plants are used in traditional Chinese, Ayurveda, Siddha, Unani, and Tibetan medicines. Ancient literature such as Rigveda, Yajurveda, Atharvaveda, CharakSamhita, and Sushrut Samhita also describes the use of plants for the treatment of various health problems. In recent times, the focus on plant research has increased worldwide, and a large body of evidence has been collected to show the immense potential of medicinal plants used in various traditional systems.Materials and Methods: The present study was carried out to evaluate the hepatoprotective activity of ethanolic extract of Cnidoscolus Phyllacanthus(ECP) leaves against D-galactosamine induced liver damage in Wistar rats. Hepatotoxicity was induced by D-Galactosamine (270 mg/kg body weight) administered intraperitoneally (i.p.) on the 14th day of a total two-week experiment. In contrast, the extract of the investigated plant was given orally throughout the whole experiment at 200 and 400 mg/kg body weight. Silymarin (100 mg/kg body weight) was given orally as a standard hepatoprotective drug.Results and Discussion: Histological studies showed that 400 mg/kg CP attenuated hepatocellular necrosis in d-GalN intoxicated rats. It was concluded from the results that the ethanolic extract of Cnidoscolus Phyllacanthus leaves reduces D-galactosamine-induced hepatotoxicity in rats.
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