Remineralization Effect of Xylitol Chewing Gum Containing Gloiopeltis furcata Extract and Calcium Hydrogenphosphate on Initial Caries-like Enamel Lesions

: The objective of the present study was to investigate the beneficial effects of xylitol chewing gum containing Gloiopeltis furcata extract and calcium hydrogenphosphate on remineralization of initial caries like enamel lesions. Initial caries-like enamel lesions were artificially prepared by demineralizing human enamel blocks with a O.01M acetate buffer (pH 4.0) at 50℃ . We investigated sucrose gum (control), xylitol gum, and xylitol gum containing G. furcata extract and calcium hydrogenphosphate . In the in vitro intvestiga- tion,the enamel blocks having initial caries-like enamel lesions were immersed in a remineralizing solution containing the extract of each chewing gum at 37℃ for 2 weeks , and then evaluated for degrees of remineralization by contact microradiography . The remineralizing potential of each chewing gum in vivo was also evaluated by an oral device fixed with artificially demineralized human enamel block. Each subject was fixed on this device on the lingual surface of the mandibular molar for one week , and was given chewing gum samples 7 times a day. This in vivo study was carried out by the double-blind method .