The value of on-admission serum Sodium level on 30-day outcome in acute pulmonary embolism

Background:Hyponatremia is associated with adverse outcome in some cardiopulmonary disease such as left ventricular failure. Probable mechanism in this situation is neurohumoral activation due to hemodynamic instability. However the usefulness of serum sodium level in acute pulmonary embolism (PE) is less well studied. Objectives: To evaluate the prognostic value of hyponatremia in acute PE. Methods: From Oct 2016 to Dec 2017, by a prospective study, consecutive patients presented to ED with confirmed acute PE were included. Those with history of CHF and diuretic use were excluded. The patients were divided into two groups: hyponatremic (Na Results: Finally, 121 patients completed the follow-up (Age: 54.2±17.8, M/F: 66/55). Hyponatremic patients had significant higher on-admission PESI score and 30-day mortality rate than non-hyponatremic group (110.5±39.3 vs 92.8±40.2, P=0.03 and 32.6% vs 12.3%, p Conclusions: Hyponatremia in patients with acute PE is associated with adverse outcome in terms of in-hospital clinical severity and 30-day mortality rate.