超声和微泡造影剂对小鼠早搏的影响

D. Dalecki, C. Rota, C. H. Raeman, S. Child
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引用次数: 17

摘要

本研究探讨了微泡造影剂对超声作用下小鼠心脏早搏的影响。声学暴露包括在舒张期向小鼠心脏传递单脉冲1.2 mhz超声。研究了两种造影剂(Albunex®,Optison®)和两种脉冲持续时间(5 ms, 10 μs)。单次持续时间为10 μs的脉冲产生早缩的阈值为~ 1 MPa。使用5ms脉冲,有对比度的阈值比没有对比度的阈值低一个数量级。这些结果与空化作为这种生物效应的机制是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Premature cardiac contractions produced by ultrasound and microbubble contrast agents in mice
This study investigated the effects of microbubble contrast agents on the production of premature cardiac contractions in mice exposed to ultrasound. Acoustic exposures consisted of a single pulse of 1.2-MHz ultrasound delivered to the murine heart during diastole. Two contrast agents (Albunex®, Optison®) and two pulse durations (5 ms, 10 μs) were investigated. The threshold for producing a premature contraction with a single 10-μs duration pulse was ∼1 MPa. Using a 5-ms pulse, the threshold with contrast was an order of magnitude less than the threshold without contrast. These results are consistent with cavitation as a mechanism for this bioeffect.
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