{"title":"超声和微泡造影剂对小鼠早搏的影响","authors":"D. Dalecki, C. Rota, C. H. Raeman, S. Child","doi":"10.1121/1.1935467","DOIUrl":null,"url":null,"abstract":"This study investigated the effects of microbubble contrast agents on the production of premature cardiac contractions in mice exposed to ultrasound. Acoustic exposures consisted of a single pulse of 1.2-MHz ultrasound delivered to the murine heart during diastole. Two contrast agents (Albunex®, Optison®) and two pulse durations (5 ms, 10 μs) were investigated. The threshold for producing a premature contraction with a single 10-μs duration pulse was ∼1 MPa. Using a 5-ms pulse, the threshold with contrast was an order of magnitude less than the threshold without contrast. These results are consistent with cavitation as a mechanism for this bioeffect.","PeriodicalId":87384,"journal":{"name":"Acoustics research letters online : ARLO","volume":"223 1","pages":"221-226"},"PeriodicalIF":0.0000,"publicationDate":"2005-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":"{\"title\":\"Premature cardiac contractions produced by ultrasound and microbubble contrast agents in mice\",\"authors\":\"D. Dalecki, C. Rota, C. H. Raeman, S. Child\",\"doi\":\"10.1121/1.1935467\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study investigated the effects of microbubble contrast agents on the production of premature cardiac contractions in mice exposed to ultrasound. Acoustic exposures consisted of a single pulse of 1.2-MHz ultrasound delivered to the murine heart during diastole. Two contrast agents (Albunex®, Optison®) and two pulse durations (5 ms, 10 μs) were investigated. The threshold for producing a premature contraction with a single 10-μs duration pulse was ∼1 MPa. Using a 5-ms pulse, the threshold with contrast was an order of magnitude less than the threshold without contrast. These results are consistent with cavitation as a mechanism for this bioeffect.\",\"PeriodicalId\":87384,\"journal\":{\"name\":\"Acoustics research letters online : ARLO\",\"volume\":\"223 1\",\"pages\":\"221-226\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acoustics research letters online : ARLO\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1121/1.1935467\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acoustics research letters online : ARLO","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1121/1.1935467","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Premature cardiac contractions produced by ultrasound and microbubble contrast agents in mice
This study investigated the effects of microbubble contrast agents on the production of premature cardiac contractions in mice exposed to ultrasound. Acoustic exposures consisted of a single pulse of 1.2-MHz ultrasound delivered to the murine heart during diastole. Two contrast agents (Albunex®, Optison®) and two pulse durations (5 ms, 10 μs) were investigated. The threshold for producing a premature contraction with a single 10-μs duration pulse was ∼1 MPa. Using a 5-ms pulse, the threshold with contrast was an order of magnitude less than the threshold without contrast. These results are consistent with cavitation as a mechanism for this bioeffect.