{"title":"肺结核(PTB)患者与健康人群相比血清microRNA-21的上调","authors":"A. Upadhyay","doi":"10.18782/2320-7051.7839","DOIUrl":null,"url":null,"abstract":"Tuberculosis is a lethal disease worldwide due to absences of early diagnostic processes. microRNAs have been denoted their functional and diagnostic potential in various diseases like cancer and tuberculosis. In the present study, we performed the miRNA isolation from the clinical confirm pulmonary tuberculosis (PTB) and healthy control cases. We have observed the up-regulation of serum microRNA-21 in serum sample of pulmonary tuberculosis (PTB) patients. Our results based on qRT-PCR confirmation and receiver operational curve (ROC) analysis indicate that the serum microRNA-21 can be explored as potential non invasive biomarker for early detection of pulmonary tuberculosis infection in human.","PeriodicalId":14249,"journal":{"name":"International Journal of Pure & Applied Bioscience","volume":"152 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Up-regulation of serum microRNA-21 in patients with Pulmonary Tuberculosis (PTB) as compare to healthy individuals\",\"authors\":\"A. Upadhyay\",\"doi\":\"10.18782/2320-7051.7839\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tuberculosis is a lethal disease worldwide due to absences of early diagnostic processes. microRNAs have been denoted their functional and diagnostic potential in various diseases like cancer and tuberculosis. In the present study, we performed the miRNA isolation from the clinical confirm pulmonary tuberculosis (PTB) and healthy control cases. We have observed the up-regulation of serum microRNA-21 in serum sample of pulmonary tuberculosis (PTB) patients. Our results based on qRT-PCR confirmation and receiver operational curve (ROC) analysis indicate that the serum microRNA-21 can be explored as potential non invasive biomarker for early detection of pulmonary tuberculosis infection in human.\",\"PeriodicalId\":14249,\"journal\":{\"name\":\"International Journal of Pure & Applied Bioscience\",\"volume\":\"152 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Pure & Applied Bioscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18782/2320-7051.7839\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pure & Applied Bioscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18782/2320-7051.7839","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Up-regulation of serum microRNA-21 in patients with Pulmonary Tuberculosis (PTB) as compare to healthy individuals
Tuberculosis is a lethal disease worldwide due to absences of early diagnostic processes. microRNAs have been denoted their functional and diagnostic potential in various diseases like cancer and tuberculosis. In the present study, we performed the miRNA isolation from the clinical confirm pulmonary tuberculosis (PTB) and healthy control cases. We have observed the up-regulation of serum microRNA-21 in serum sample of pulmonary tuberculosis (PTB) patients. Our results based on qRT-PCR confirmation and receiver operational curve (ROC) analysis indicate that the serum microRNA-21 can be explored as potential non invasive biomarker for early detection of pulmonary tuberculosis infection in human.
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