{"title":"生物过程中去硫酰基化研究进展综述","authors":"Bs Wang, Wei-Hsiung Yang","doi":"10.7156/V5I2P071","DOIUrl":null,"url":null,"abstract":"Post-translational modifications to proteins are essential mechanisms for controlling functions of proteins and subsequently for regulating cell fate. SUMO modification (SUMOylation) has emerged as a critical regulatory pathway in cellular function and biological processes. DeSUMOylation (removal of SUMO conjugation) by members of SUMO-specific proteases (SENPs) family makes SUMO modification highly dynamic. In this mini-review, we briefly introduce the current knowledge regarding the regulatory pathway of deSUMOylation and focus on the recent progress of functions of SENPs in biological progresses. [N A J Med Sci. 2012;5(2):71-77.]","PeriodicalId":19338,"journal":{"name":"North American journal of medicine & science","volume":"109 1","pages":"71"},"PeriodicalIF":0.0000,"publicationDate":"2012-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent Progress of DeSUMOylation in Biological Processes: A Mini Review\",\"authors\":\"Bs Wang, Wei-Hsiung Yang\",\"doi\":\"10.7156/V5I2P071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Post-translational modifications to proteins are essential mechanisms for controlling functions of proteins and subsequently for regulating cell fate. SUMO modification (SUMOylation) has emerged as a critical regulatory pathway in cellular function and biological processes. DeSUMOylation (removal of SUMO conjugation) by members of SUMO-specific proteases (SENPs) family makes SUMO modification highly dynamic. In this mini-review, we briefly introduce the current knowledge regarding the regulatory pathway of deSUMOylation and focus on the recent progress of functions of SENPs in biological progresses. [N A J Med Sci. 2012;5(2):71-77.]\",\"PeriodicalId\":19338,\"journal\":{\"name\":\"North American journal of medicine & science\",\"volume\":\"109 1\",\"pages\":\"71\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"North American journal of medicine & science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7156/V5I2P071\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"North American journal of medicine & science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7156/V5I2P071","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Recent Progress of DeSUMOylation in Biological Processes: A Mini Review
Post-translational modifications to proteins are essential mechanisms for controlling functions of proteins and subsequently for regulating cell fate. SUMO modification (SUMOylation) has emerged as a critical regulatory pathway in cellular function and biological processes. DeSUMOylation (removal of SUMO conjugation) by members of SUMO-specific proteases (SENPs) family makes SUMO modification highly dynamic. In this mini-review, we briefly introduce the current knowledge regarding the regulatory pathway of deSUMOylation and focus on the recent progress of functions of SENPs in biological progresses. [N A J Med Sci. 2012;5(2):71-77.]
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