神经系统和肾脏。在正常和病理条件下相互作用的交叉机制

F. Yusupov, A. Yuldashev
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引用次数: 0

摘要

在生理状态下,神经系统和肾脏相互作用以维持体内正常的稳态。然而,病理条件,如高血压,肾脏本身的病理,急性和慢性,破坏这种相互作用。在各种病因的急性肾损伤(AKI)和慢性肾脏疾病(CKD)中,肾脏受损可对中枢神经系统功能产生重大影响。CKD是脑血管疾病和认知障碍发展的独立危险因素,由于许多因素,包括尿毒症毒素和磷酸盐的保留,已被认为是CKD特异性因素,负责CKD患者的大脑结构和功能改变,然而,需要进一步的研究来确定确切的发病机制。我们的综述致力于肾脏和神经系统在生理和病理生理条件下的相互作用,我们试图详细揭示肾脏病理中神经系统功能障碍的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nervous system and kidneys. Cross-mechanisms of interaction in normal and pathological conditions
In physiological states, the nervous system and kidneys interact with each other to maintain normal homeostasis in the body. However, pathological conditions such as hypertension, pathology of the kidney itself, both acute and chronic, disrupt this interaction. In acute kidney injury (AKI of various etiologies) and chronic kidney disease (CKD), damaged kidneys can have a significant impact on the function of the central nervous system. CKD is an independent risk factor for the development of cerebrovascular diseases and cognitive impairment due to many factors, including the retention of uremic toxins and phosphates, have been proposed as CKD-specific factors responsible for structural and functional cerebral changes in patients with CKD, however, additional studies are needed to determine the exact pathogenesis. Our review is devoted to the interaction of the kidney and the nervous system in physiological conditions and pathophysiological conditions, we are trying to reveal in detail the mechanisms of dysfunction of the nervous system in kidney pathologies.
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