Prevalence of meropenem and imipenem resistance in gram-negative uropathogens in ibn sina clinic in Benghazi-Libya

Background/Aims: The carbapenem resistance is increasing worldwide. Although there are a number of studies on carbapenem resistance available in western Libya, there is no adequate information in eastern Libya. The aim of the present work was to study the prevalence of both imipenem and meropenem in uropathogens in one hospital in Benghazi, a city in Libya, to know the magnitude of resistance caused by these groups of bacteria. Subjects and Methods: A total of 1011 samples of patients with urinary tract infection were collected from August 1, 2019, to April 30, 2020. Identification of the isolates was done and the antibiotic susceptibility of different uropathogens was tested for their imipenem and meropenem susceptibility. Results: The prevalence of Escherichia coli was 68.8%, followed by Klebsiella pneumonia and Proteus mirabilis (12.4% and 4.8%, respectively). The prevalence of Pseudomonas aeruginosa was also (12.4%), and the Acinetobacter baumannii comes next by 1.6%. Conclusions: Compared to different results done in different parts of Libya, the prevalence of carbapenem was increased and this expanded to other Enterobacteriaceae as P. mirabilis that has not declared in previous data in different regions in Libya.