小鼠8号染色体SKI-1/S1P蛋白酶基因(位点符号Mbtps 1)的遗传定位

H. Tadros, N. Seidah, M. Chrétien, M. Mbikay
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引用次数: 3

摘要

枯草素/酮蛋白同工酶-1 (SKI-1),也被称为Site-1蛋白酶(S1P),是一种高尔基蛋白酶,介导胆固醇调节元件结合蛋白(SREBPs) 1和2前体的蛋白水解活化,SREBPs 1和2是两种转录因子,调节多种参与胆固醇和脂质代谢的基因的表达。通过对小鼠亚种间回交的基因组DNA进行PCR和RFLP分析,我们将SK1-/S1P基因(位点符号:Mbtps 1)定位到小鼠8号染色体的远端部分,该区域与人类染色体16q24区域具有同源性,该区域的同源物先前已被定位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic Mapping of the Gene for SKI-1/S1P Protease (locus Symbol Mbtps 1) to Mouse Chromosome 8
Subtilisin/kexin isozyme-1 (SKI-1), otherwise known as Site-1 protease (S1P), is a Golgi proteinase mediating the proteolytic activation of the precursor to sterol-regulated element-binding proteins (SREBPs) 1 and 2, two transcriptional factors that regulate expression of a variety of genes involved in cholesterol and lipid metabolism. Using PCR and RFLP analysis on a panel of genomic DNA from a mouse intersubspecific backcross, we have mapped the SK1-/S1P gene (locus symbol: Mbtps 1) to the distal part of mouse chromosome 8, in a region that exhibits synteny homology to the human chromosome 16q24 region where its orthologue had been previously mapped.
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