脂肪酸酰胺与乙醇胺和甘氨酸在模拟周围神经病变中注射促炎性和抗炎细胞因子的特征

Q4 Medicine

Proceedings of the National Academy of Sciences of Belarus, Medical series Pub Date : 2023-09-01 DOI:10.29235/1814-6023-2023-20-3-183-190

А. С. Доронькина, И. П. Жаворонок, В. Г. Богдан, A. S. Doronkina, I. P. Zhavoronok, Vasily G. Bogdan

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引用次数: 0

摘要

研究脂肪酸酰胺阻断膜孤儿体GPR18、GPR55和核PPARα受体对实验性周围神经病变大鼠促炎性和抗炎性细胞因子水平的影响。已证实PEA和SEA对神经病变实验动物的抗炎作用是通过核PPARα受体实现的。然而，PGlyA在大鼠周围神经病变模型中没有抗炎作用。

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Profile of pro- and anti-inflammatory cytokines during injection of fatty acid amides with ethanolamine and glycine in modeling peripheral neuropathy

The effect of fatty acid amides during the blockade of membrane orphan GPR18, GPR55 and nuclear PPARα receptors on the level of pro- and anti-inflammatory cytokines in rats with experimental peripheral neuropathy was studied. It has been proven that the anti-inflammatory action of PEA and SEA in experimental animals with neuropathy is carried out through nuclear PPARα receptors. However, PGlyA has no anti-inflamatory effects in a rat model of peripheral neuropathy.

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来源期刊

Proceedings of the National Academy of Sciences of Belarus, Medical series Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量