阿尔茨海默病的转录后调控受损

Pub Date : 2012-08-01 DOI:10.3724/SP.J.1206.2012.00211

Zhu Li, 朱笠, Liu Jianghong, Wu Ying

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引用次数: 1

摘要

转录后调控在神经系统的发育和维持中起着核心作用。转录后调控缺陷导致神经退行性疾病。越来越多的证据表明，相关基因的转录后调控受损有助于神经退行性过程，如阿尔茨海默病(AD)。本文综述了人类tau基因(MAPT)选择性剪接调节的中断和microRNA表达的改变在包括AD在内的神经退行性疾病发病机制中的作用。本文就转录后调控在AD发病中的作用及机制作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Impaired Post-transcriptional Regulation in Alzheimer′s Disease

Post-transcriptional regulation plays a central role in the development and maintenance of the nervous system.Defects in post-transcriptional regulation lead to neurodegenerative diseases.Mounting evidence suggests that the impaired post-transcriptional regulation of associated genes contribute to the neurodegenerative process,such as Alzheimer's disease(AD).This review discusses the role of disruption of alternative splicing regulation of the human tau gene(MAPT) and alterations of microRNA expression in the pathogenesis of neurodegeneration including AD.A brief overview is provided for the role and the mechanism of post-transcriptional regulation in AD pathogenesis.

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