苯并噻唑类异恶唑席夫碱的合成及抗菌性能评价

IF 0.5 4区化学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-11-18 DOI:10.56042/ijcb.v60i11.54954

G. Mallikarjun, A. Raju, J. Yadav

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引用次数: 0

摘要

制备了一系列新的苯并噻唑类异恶唑希夫碱衍生物，并通过1h和13c NMR、ESI-MS和IR光谱对其进行了表征。这些化合物已被进一步筛选其对一组微生物的抗菌活性。其中化合物12d、12g和12l对所有被试菌株均表现出良好的抑菌活性，MIC值在3.9 ~ 62.5µg/mL之间。此外，化合物12d、12g和12l表现出良好的抗真菌活性，MIC值在7.8 - 32.5µg/mL之间。进一步的研究正在进行中，以确定这些潜在化合物的抗真菌分子机制。

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Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases

A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1 H and 13 C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d , 12g and 12l demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5 µg/mL. Further, compounds 12d , 12g and 12l exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5 µg/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.

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来源期刊

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry 化学-有机化学

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".