{"title":"眼碱烧伤后干眼表现及TGF-β表达的研究","authors":"Bo Jiang, Tao Li, Man She, Xiaoqian Yao","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.11.001","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the manifestation of dry eye and TGF-β expression in patients after ocular alkali burns. \n \n \nMethods \nThis is a case-control study. Total of 33 eyes of 26 cases with alkali burns of I-IV degrees from Jan.2017 to Jun.2018 in this hospital were selected as observation group, and 10 eyes of 10 cases of normal people were selected as control group. The followed-up time was 3 months. The visual acuity, intraocular pressure, BUT, SchirmerⅠtest, lacrimal rivus height and corneal thickness were observed at 1 day, 1 and 3 months after ocular alkali burn. The protein expression of TGF-β1 and TGF-β2 were examined with western-blot analysis. \n \n \nResults \nBUT and Schirmer I test in the observation group were lower than those in the control group at 3 months after ocular alkali burn (P<0.05). The corneal thickness and the lacrimal rivus height at each time after ocular alkali burn were higher than those in the control group(P<0.05). The protein expressions of TGF-β1 and TGF-β2 were significantly negatively correlated with BUT(P=0.046, 0.036), and TGF-β2 was significantly positively correlated with corneal thickness (P=0.024). \n \n \nConclusion \nOcular alkali burns can cause dry eye, and the expressions of TGF-β1 and TGF-β2 in tears may be related to the occurrence of dry eye after ocular alkali burn. \n \n \nKey words: \nBurn, alkali, ocular; Dry eye; OCT; TGF-β1; TGF-β2","PeriodicalId":10126,"journal":{"name":"中华眼外伤职业眼病杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study of manifestations of dry eye and TGF-β expression after ocular alkali burn\",\"authors\":\"Bo Jiang, Tao Li, Man She, Xiaoqian Yao\",\"doi\":\"10.3760/CMA.J.ISSN.2095-1477.2019.11.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo investigate the manifestation of dry eye and TGF-β expression in patients after ocular alkali burns. \\n \\n \\nMethods \\nThis is a case-control study. Total of 33 eyes of 26 cases with alkali burns of I-IV degrees from Jan.2017 to Jun.2018 in this hospital were selected as observation group, and 10 eyes of 10 cases of normal people were selected as control group. The followed-up time was 3 months. The visual acuity, intraocular pressure, BUT, SchirmerⅠtest, lacrimal rivus height and corneal thickness were observed at 1 day, 1 and 3 months after ocular alkali burn. The protein expression of TGF-β1 and TGF-β2 were examined with western-blot analysis. \\n \\n \\nResults \\nBUT and Schirmer I test in the observation group were lower than those in the control group at 3 months after ocular alkali burn (P<0.05). The corneal thickness and the lacrimal rivus height at each time after ocular alkali burn were higher than those in the control group(P<0.05). The protein expressions of TGF-β1 and TGF-β2 were significantly negatively correlated with BUT(P=0.046, 0.036), and TGF-β2 was significantly positively correlated with corneal thickness (P=0.024). \\n \\n \\nConclusion \\nOcular alkali burns can cause dry eye, and the expressions of TGF-β1 and TGF-β2 in tears may be related to the occurrence of dry eye after ocular alkali burn. \\n \\n \\nKey words: \\nBurn, alkali, ocular; Dry eye; OCT; TGF-β1; TGF-β2\",\"PeriodicalId\":10126,\"journal\":{\"name\":\"中华眼外伤职业眼病杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华眼外伤职业眼病杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.11.001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华眼外伤职业眼病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.11.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Study of manifestations of dry eye and TGF-β expression after ocular alkali burn
Objective
To investigate the manifestation of dry eye and TGF-β expression in patients after ocular alkali burns.
Methods
This is a case-control study. Total of 33 eyes of 26 cases with alkali burns of I-IV degrees from Jan.2017 to Jun.2018 in this hospital were selected as observation group, and 10 eyes of 10 cases of normal people were selected as control group. The followed-up time was 3 months. The visual acuity, intraocular pressure, BUT, SchirmerⅠtest, lacrimal rivus height and corneal thickness were observed at 1 day, 1 and 3 months after ocular alkali burn. The protein expression of TGF-β1 and TGF-β2 were examined with western-blot analysis.
Results
BUT and Schirmer I test in the observation group were lower than those in the control group at 3 months after ocular alkali burn (P<0.05). The corneal thickness and the lacrimal rivus height at each time after ocular alkali burn were higher than those in the control group(P<0.05). The protein expressions of TGF-β1 and TGF-β2 were significantly negatively correlated with BUT(P=0.046, 0.036), and TGF-β2 was significantly positively correlated with corneal thickness (P=0.024).
Conclusion
Ocular alkali burns can cause dry eye, and the expressions of TGF-β1 and TGF-β2 in tears may be related to the occurrence of dry eye after ocular alkali burn.
Key words:
Burn, alkali, ocular; Dry eye; OCT; TGF-β1; TGF-β2
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