肉毒杆菌神经毒素:既是毒药也是药物。肉毒杆菌治疗和医源性肉毒杆菌中毒

V. Nikiforov
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引用次数: 0

摘要

肉毒杆菌神经毒素(BnT)是世界上已知的所有毒药中最有效的。在过去的两个世纪里,人们对它的结构和功能进行了详细的研究,得到了它的纯净形式。对BnT作用机制的了解已经确定了其可能用途的两个方向:阴性,作为生物(毒素)武器;阳性-作为消除病理性肌肉高张力,神经性疼痛的药物,可用于美学目的(“美容注射”)。讲座给出了这两个方向的发展年表,并详细分析了BnT在治疗和美容方面的医疗用途。特别注意肉毒杆菌治疗的副作用和克服它们的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Botulinum neurotoxin: both poison and medicine. Botulinum therapy and iatrogenic botulism
Botulinum neurotoxin (BnT) is the most potent of all the poisons known to the world. Over the past two centuries, its structure and functions have been studied in detail, it is obtained in its pure form. Knowledge of the mechanisms of action of BnT has determined two directions of its possible use: negative, as a biological (toxin) weapon, and positive - as a drug that eliminates pathological muscle hypertonicity, neuropathic pain and can be used for aesthetic purposes ("beauty injections"). The lecture gives a chronology of the development of both directions and a detailed analysis of the medical use of BnT both therapeutically and cosmetically. Particular attention is paid to the side effects of botulinum therapy and ways to overcome them.
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