一种检测药物和生物化合物中抗坏血酸含量的灵敏、简便的电化学技术

IF 2.9 Q2 ELECTROCHEMISTRY

Journal of Electrochemical Science and Engineering Pub Date : 2022-08-10 DOI:10.5599/jese.1366

S. Z. Mohammadi, Farideh Mousazadeh

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引用次数: 1

摘要

本研究研究了石墨烯- cos2纳米复合材料修饰的玻璃碳电极(GCE)用于抗坏血酸的电化学传感。采用差分脉冲伏安法(DPV)、线性扫描伏安法(LSV)和计时伏安法(CHA)对改性电极的电化学性能进行了检测。抗坏血酸在石墨烯- cos2 /GCE上的电化学行为表现出比裸GCE更高的氧化电流和更低的氧化电位。在最佳实验条件下，该传感器在电流与抗坏血酸浓度范围(0.15 ~ 245.0 μM)之间具有良好的线性响应，检测限低至0.05 μM。最后，将石墨烯- cos2纳米复合材料修饰的GCE应用于实际样品中抗坏血酸的测定，显示出良好的回收率。

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A sensitive and simple electrochemical technique for detecting ascorbic acid content in pharmaceutical and biological compounds

In the current study, a glassy carbon electrode (GCE) modified with graphene-CoS2 nanocomposite was investigated for electrochemical sensing of ascorbic acid. The electrochemical performance of the modified electrode was examined using differential pulse voltammetry (DPV), linear sweep voltammetry (LSV) and chronoamperometry (CHA) techniques. The electrochemical behavior of ascorbic acid at the graphene-CoS2/GCE displayed a higher oxidation current and lower oxidation potential than bare GCE. Under the optimal experimental conditions, the sensor presented a good linear response between the current and the ascorbic acid concentration range of 0.15–245.0 μM, with a low detection limit of 0.05 μM. Finally, the graphene-CoS2 nanocomposite-modified GCE was applied for the determination of ascorbic acid in real samples and displayed excellent recoveries.

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来源期刊

Journal of Electrochemical Science and Engineering ELECTROCHEMISTRY-

CiteScore

3.60

自引率

27.30%

发文量

审稿时长

6 weeks