Zannatul Ferdous Miftah, Jyosna Khanam, Sheikh Faisal Assadullah Mahadi, S. N. Islam
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摘要

本文介绍了几种民族植物性食品的抗氧化能力(AC)和总酚含量(TPC)及其在缓解实验性应激性抑郁大鼠模型中的治疗作用。通过自由基清除活性测定抗氧化能力,用Folin-Ciocalteau法测定TPC。化学应激源利血平诱导抑郁。通过强迫游泳试验(FST)和悬尾试验(TST)的行为改变、氧化应激标志物丙二醛(MDA)、空腹血糖(FBG)、肾上腺和脑质量的变化来评价民族食品对抑郁症的缓解作用。IC50值为74.814µg/ml ~ 411.895µg/ml。IC50值越低,抗氧化活性越强。因此,最强的AC是在Gondhovatali,其次是Sabarang和Titbegun。TPC范围为85.5±5.51 ~ 650±2.75 mgGAE/100g。jamalu的TPC值最高,其次是Gondhovatali、Titbegun和Khudemanik。实验组和对照组在肾上腺和脑的重量上有显著差异。与抑郁对照组相比,植物提取物饲喂组的生化应激指标(MDA、FBG)和行为测试(TST、FST)差异有统计学意义,但与抗抑郁药氯丙咪嗪治疗组和基线对照组基本相似。结果表明,选用TPC较高、IC50较低的民族植物性食物可显著缓解大鼠抑郁症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phenol Content and Antioxidant Capacity of Selected Ethnic Plant Foods: Alleviation of Experimental Depression.
This article describes the antioxidant capacity (AC) and total phenol content (TPC) of selected ethnic plant foods and their therapeutic uses in alleviating experimental stress-induced depression in rat model. Antioxidant capacity was determined by radical scavenging activity and TPC was estimated by Folin-Ciocalteau method. Depression was induced by chemical stressor- reserpine. Alleviation of depression by the ethnic foods was evaluated by behavioral changes in Forced Swim Test (FST) and Tail Suspension Test (TST), and by analysis of oxidative stress marker Malondialdehyde (MDA), fasting blood glucose (FBG) and change of weight of adrenal gland and brain. Antioxidant capacity was determined by IC50 value, which was ranged from 74.814 µg/ml to 411.895 µg/ml. The lowest IC50 value indicates the strongest antioxidant activity. Hence, the strongest AC was found in Gondhovatali followed by Sabarang and Titbegun. TPC ranged from 85.5 ± 5.51 to 650 ± 2.75 mgGAE/100g. Jaamalu was found to have the highest TPC value followed by Gondhovatali, Titbegun and Khudemanik. The difference among experimental and control groups was found to be significant in the weight of adrenal gland and brain. Biochemical stress indicators (MDA, FBG) and behavioral tests (TST, FST) showed significant differences among plant extract fed groups compared to that of depressed control group, but was found to be almost similar to antidepressant clomipramine treated and baseline control groups. The data indicated that the selected ethnic plant foods containing higher TPC and lower IC50 values significantly alleviated depression symptoms in the rats.
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