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Revista Latinoamericana de Cirugía Ortopédica Pub Date : 2016-10-01 DOI:10.1016/j.rslaot.2017.04.002

Horacio Alberto Caviglia , Gustavo Alberto Galatro , Noemí Moretti , Carla Daffunchio , María Eulalia Landro , Ana Laura Douglas Price

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引用次数: 0

摘要

滑膜炎是由含铁血黄素关节内沉积引起的血友病最常见的并发症之一。患者与方法1992 ~ 2001年对99例血友病伴124例滑膜炎患者进行关节内注射利福平治疗。平均随访时间为5年。平均年龄15岁。12例患者有因子VIII抑制剂。其中肘关节28个(22.6%)，踝关节19个(15.3%)，膝关节77个(62.1%)。各关节平均注射次数为:肘关节4次，踝关节3次，膝关节7次。结果101个(81.5%)关节表现为良好，17个(13.7%)关节表现为良好，6个(4.8%)关节表现为不良。小关节(踝关节和肘关节)比大关节(膝关节)效果更好(p <0001)。严重血友病患者的预后比轻度或中度血友病患者差。滑膜炎发病时间影响患者预后。无复发的患者效果良好。结论利福平联合滑膜成形术是治疗滑膜炎的一种有效方法，尤其对发展周期短的小关节疗效显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sinoviortesis química con rifampicina en pacientes hemofílicos

Aim

Synovitis is one of the most frequent complications of haemophilic disease produced by intra-articular deposits of hemosiderin.

Patients and methods

99 patients with haemophilia with 124 synovitis joints were treated with intra-articular rifampicin injection, between 1992 to 2001. The mean follow up was 5 years. Mean age was 15 years old. 12 patients had inhibitors to factor VIII. The joints affected were: 28 (22.6%) elbows, 19 (15.3%) ankles and 77 (62.1%) knees. The mean number or injections according each joint was: elbow: 4, ankle: 3 and knee: 7.

Results

101 (81,5%) joints showed excellent results, 17 (13.7%) good results and 6 (4.8%) poor results. Small joints (ankle and elbow) showed better results than big ones (knee) (p < 0,001). Patients with severe hemophilia had worse outcomes than patients with mild or moderate disease. Time of synovitis affected the outcome of the patients. Excellent results were seen in patients without recurrence.

Conclusion

Synoviorthesis with rifampicin seems to be an effective method for the treatment of synovitis, with excellent results specially in small joints with short period of evolution.

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Revista Latinoamericana de Cirugía Ortopédica

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