TREM2和TC2N基因在人乳腺癌组织中的表达分析

IF 0.4 Q4 ONCOLOGY
Hadi Chenaneh, Mojtaba Rashidi, K. Ahmadi Angali, M. Adelipour
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引用次数: 0

摘要

背景:由于乳腺癌是全世界女性中最常见的癌症类型,寻找新的生物标志物用于乳腺癌的早期诊断是非常宝贵的。目的:本研究评估伊朗乳腺癌患者髓样细胞2 (TREM2)和串联C2结构域核蛋白(TC2N)基因触发受体的mRNA表达。方法:我们从伊朗妇女中获得50例乳腺癌性肿瘤和相应的邻近非癌性组织。采用实时荧光定量聚合酶链反应(q-RT-PCR)检测TREM2和TC2N基因的表达。此外,我们还研究了TREM2和TC2N水平与各种临床病理特征之间的关系。结果:乳腺癌组织中TREM2和TC2N mrna水平较癌旁非癌组织明显升高(P < 0.05)。在评估的临床病理特征中,肿瘤大小、坏死和淋巴组织侵袭与TREM2高表达显著相关。TC2N表达升高与肿瘤分级也有显著关系。TREM2的敏感性和特异性分别为84%和94%,TC2N的敏感性和特异性分别为72%和100%。结论:数据提示TREM2的表达,而不是TC2N,可能是乳腺癌诊断的合适生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression Analysis of TREM2 and TC2N Genes in Human Breast Cancer Tissues
Background: Since breast cancer is the most common type of cancer in women around the world, finding new biomarkers for early diagnosis of breast cancer is invaluable. Objectives: This research assessed the mRNA expression of triggering receptors expressed on myeloid cell 2 (TREM2) and tandem C2 domains nuclear protein (TC2N) genes among Iranian patients with breast cancer. Methods: We acquired 50 samples of cancerous breast tumors and corresponding adjacent non-cancerous tissues from Iranian women. The gene expression of TREM2 and TC2N was measured by quantitative real-time polymerase chain reaction (q-RT-PCR). In addition, the association between TREM2 and TC2N levels with various clinicopathologic characteristics was also investigated. Results: The increased levels of TREM2 and TC2N mRNAs were shown in breast cancerous tissues in comparison with adjacent non-cancerous tissues (P < 0.05). Among the clinicopathological characteristics evaluated, tumor size, necrosis, and lymphatic tissue invasion were significantly associated with high TREM2 expression. A significant relationship was also seen between increased TC2N expression and tumor grade. Sensitivity and specificity were shown at 84% and 94%, respectively, for TREM2 and 72% and 100% for TC2N. Conclusions: The data suggest that TREM2 expression, but not TC2N, could be a suitable biomarker for breast cancer diagnosis.
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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