药物性肝毒性:综述

A. Kshirsagar, Y. Vetal, P. Ashok, Pradnya A. Bhosle, D. Ingawale
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引用次数: 22

摘要

肝脏是人体最大的器官,它正在进化,以维持身体的内部环境,并保护自己免受其功能过程中面临的挑战。它是一个具有多种功能的重要器官。它不仅在代谢、合成和储存中起重要作用,而且在许多内源性和外源性化合物的解毒和转化为毒性较小的物质排泄中起重要作用。肝毒性指的是化学引起的肝损伤。某些药物如果服用过量,有时甚至在治疗范围内使用,可能会损害肝脏。肝脏在转化和清除化学物质中起着核心作用,并且容易受到这些物质的毒性影响。本文综述了引起肝毒性的各种药物、各种类型的药物引起的肝毒性及其机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Drug Induced Hepatotoxicity: A Comprehensive Review
Liver, the largest organ in the body is being evolved to maintain the body’s internal milieu and also protect itself from the challenges it faces during its functioning. It is a vital organ having diverse functions. It plays an important role not only in the metabolism, synthesis and storage but also in the detoxification of many endogenous and exogenous compounds and converting them to less toxic substances for excretion. Hepatotoxicity implies chemical-driven liver damage. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the liver. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. The present review provides an overview of various drugs causing hepatotoxicity, various types of drug induced hepatotoxicity and their mechanisms.
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