多壁碳纳米管对人乳腺腺癌细胞系的细胞毒性作用

CAS 2012 (International Semiconductor Conference) Pub Date : 2012-10-01 DOI:10.1109/SMICND.2012.6400701

S. Bellucci, S. Dinicola, P. Coluccia, M. Bizzarri, A. Catizone, F. Micciulla, I. Sacco, G. Ricci, A. Cucina

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引用次数: 2

摘要

用0.1 mg/ml MWCNTs、MWCNTs- cooh或MWCNTs- oh处理人乳腺腺癌细胞系MCF-7 72小时，可诱导细胞增殖减少和细胞周期s期细胞百分比减少。此外，所有类型的MWCNTs均诱导凋亡细胞增加。总的来说，这些数据表明，所有类型的MWCNTs的细胞毒性作用都是通过增殖速率的降低和凋亡细胞死亡的增加来介导的。所有类型的MWCNTs的生物学效应都可以用它们的细胞内化来解释。

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Multiwalled carbon nanotubes-induced cytotoxic effects on human breast adenocarcinoma cell line

Treatment of the human breast adenocarcinoma cell line, MCF-7, with 0.1 mg/ml of MWCNTs, MWCNTs-COOH, or MWCNTs-OH for 72 hours induced both a decrease in cell proliferation and a reduction of the percentage of cells in S-phase of cell cycle. Moreover, all types of MWCNTs induced an increase in apoptotic cells. Overall, these data indicated that the cytotoxic effects of all types of MWCNTs are mediated both from a decrease in the proliferation rate and from an increase of apoptotic cell death. The biological effects of all types of MWCNTs could be explained with their cellular internalization.

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CAS 2012 (International Semiconductor Conference)

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