基于生物碱的杂交分子

O. Nurkenov, S. Fazylov, G.K. Mukusheva, Ye.V. Minayeva, I. Kulakov, Z. Nurmaganbetov, A. S. Kishkentaeva, A.R. Zhasymbekova
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引用次数: 0

摘要

本文综述了近年来生物碱分子杂化衍生物的合成研究进展。与此同时,已经有分析方法获得含有天然化合物分子片段与其他具有生物活性的植物代谢物结合的杂交结构,作为开发新的药理价值药物的先导化合物,目的是创造新的原研药物。天然生物碱核苷位置上的各种芳香族和杂环取代基将药效残基组合在一个分子中,为所获得的多官能衍生物的后续化学修饰和新的多样化生物活性开辟了新的可能性。在这些化合物(或其前体)定向转化的基础上,已经发展出有效的合成方法。这些系列的组合化合物具有广泛的药理特性和低毒性的组合是有希望的。鉴于基于生物碱分子的组合衍生物的制备研究尚不充分,新化合物的靶向合成在新药制备和有机合成新方法的开发以及新系列化合物的分子立体化学测定等方面都具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HYBRID MOLECULES BASED ON ALKALOIDS
This review has been summarized the data on the synthesis of new hybrid derivatives based on alkaloid molecules. At the same time, there have been analyzed methods for obtaining hybrid structures containing fragments of natural compounds molecules in combination with other biologically active plant metabolites, as leading compounds for the development of new pharmacologically valuable agents, with the aim of creating new original drugs. The combination of pharmacophoric residues in one molecule, namely various aromatic and heterocyclic substituents in the nucleoside position of natural alkaloids, opens up new possibilities for both the subsequent chemical modification of the polyfunctional derivatives obtained and their new diverse biological activity. Effective methods of synthesis have been developed on the basis of directed transformations of these compounds (or their precursors). A wide range of pharmaco-logical properties of combined compounds of these series with a combination of low toxicity is promising. Considering that the preparation of combined derivatives based on alkaloid molecules has been insufficiently studied, the targeted synthesis of new com-pounds is of interest both in terms of new medicinespreparation and the development of new methods of organic synthesis, as well as the molecules stereochemistry determination of a new series of compounds.
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