白细胞介素-6和降钙素原作为炎症生物标志物在评估COVID-19疾病严重程度中的作用

PAFMJ Pub Date : 2021-12-31 DOI:10.51253/pafmj.v71i6.6977

Zeeshan Ayub, Azeema Ahmed, F. Afzal, S. Bashir, H. Iqbal, K. Nawaz

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引用次数: 1

摘要

目的:探讨白细胞介素-6、降钙素原与胸部高分辨率计算机断层扫描(HRCT) COVID-19严重程度的关系。研究设计:随机对照试验(NCT04945811)。学习地点和时间:奎达联合军队医院病理科，2020年4月至2021年5月。方法:对2020年4月至2021年5月奎达联合军队医院病理部收治的100例COVID-19阳性患者的血清白细胞介素-6和降钙素原进行评估，并将其水平与胸部HRCT肺部受累程度相关。结果:97例患者血清白细胞介素-6水平显著升高，平均水平为20.43±19.66 (pg/ml)。95例患者血清降钙素原水平也显著升高，平均水平为0.43±0.24 (ng/ml)。结论:白细胞介素-6和降钙素原是诊断和预测COVID-19肺炎严重程度的重要生物标志物。

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ROLE OF INTERLEUKIN-6 AND PROCALCITONIN AS INFLAMMATORY BIOMARKERS IN EVALUATING COVID-19 DISEASE SEVERITY ON HRCT CHESTAN EXPERIENCE AT CMH QUETTA

Objective: To explore the relation of Interleukin-6 and Procalcitonin with COVID-19 severity on high resolution computerized tomogram (HRCT) chest. Study Design: Randomized Control Trial (NCT04945811). Place and Duration of study: Pathology Department, Combined Military Hospital Quetta, from April 2020 to May 2021. Methodology: Serum Interleukin-6 and Procalcitonin of 100 consenting COVID-19 positive patients from April 2020 to May 2021 were assessed at Pathology department Combined Military Hospital Quetta and their levels were correlated with severity of lung involvement on HRCT Chest Results: Serum Interlukin-6 levels were significantly raised in 97 patients with mean levels of 20.43 ± 19.66 (pg/ml). Serum procalcitonin levels were also significantly raised in 95 patients with mean levels of 0.43 ± 0.24 (ng/ml). Conclusion: Interlukin-6 and procalcitonin are important biomarkers for diagnosis and predicting severity of COVID-19 pneumonia.

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PAFMJ

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