S. Malik, Suparna Ghosh, B. Jain, Archana Singh, M. Bhattacharya
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引用次数: 16
摘要
本文研究了利尿剂西帕胺席夫碱金属配合物的合成和表征。该双齿配体是由5-氨基磺酰基-4-氯- n -2,6-二甲基苯基-2-羟基苯酰胺(西帕胺)与水杨醛以1:1的摩尔比缩合而成。利用该双齿配体,合成了通式ML2的Hg(II)、Zn(II)和VO(IV)配合物。通过摩尔电导、元素分析、磁化率、红外光谱、电子光谱、质谱和粒度分析等方法对合成的配合物进行了表征。元素分析数据表明,其化学计量比为1:2 [M: L]。摩尔电导测量表明,所有配合物本质上都是非电解的。红外光谱数据表明配体与中心金属离子通过去质子化的酚氧和亚甲基氮原子进行配位。光谱研究表明,Hg(II)、Zn(II)配合物呈四面体结构,VO(IV)配合物呈方锥体结构。对纯药物、合成配体和金属配合物对黑曲霉和黄曲霉的抑菌活性进行了筛选。并对该配体及其Hg(II)和VO(IV)配合物的利尿活性进行了筛选。
Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug
The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.