{"title":"环己基锡N-水杨酸酯的合成、表征及抗菌活性研究","authors":"Laijin Tian","doi":"10.21060/CIS.V4I2.2369","DOIUrl":null,"url":null,"abstract":"Abstract : Two new cyclohexyltin N- (salicylidene)valinates, [2-HOC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 3 ( 1 ) and [2-OC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 2 ( 2 ) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and 1 H NMR. The crystal structure of 2 has been determined by X-ray single crystal diffraction. In the complexes, the carboxylate is monodentate. Complex 1 is a four-coordinated tin compound, and 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli .","PeriodicalId":10648,"journal":{"name":"Communications in Inorganic Synthesis","volume":"8 1","pages":"12-16"},"PeriodicalIF":0.0000,"publicationDate":"2016-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Synthesis, characterization and antibacterial activity of cyclohexyltin N-(salicylidene)valinates\",\"authors\":\"Laijin Tian\",\"doi\":\"10.21060/CIS.V4I2.2369\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract : Two new cyclohexyltin N- (salicylidene)valinates, [2-HOC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 3 ( 1 ) and [2-OC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 2 ( 2 ) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and 1 H NMR. The crystal structure of 2 has been determined by X-ray single crystal diffraction. In the complexes, the carboxylate is monodentate. Complex 1 is a four-coordinated tin compound, and 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli .\",\"PeriodicalId\":10648,\"journal\":{\"name\":\"Communications in Inorganic Synthesis\",\"volume\":\"8 1\",\"pages\":\"12-16\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Communications in Inorganic Synthesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21060/CIS.V4I2.2369\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communications in Inorganic Synthesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21060/CIS.V4I2.2369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
摘要:合成了两个新的环己基锡N-(水杨基)验证物[2- hoc 6 H 4 CH=NCH(CH(CH 3) 2)COO]SnCy 3(1)和[2- oc 6 H 4 CH=NCH(CH(CH 3) 2)COO]SnCy 2 (2) (Cy =环己基)，并通过元素分析、IR和1h NMR进行了表征。用x射线单晶衍射测定了2的晶体结构。在配合物中，羧酸盐是单齿的。配合物1是一个四配位锡化合物，配合物2具有扭曲的三角双锥体几何形状，其轴向位置由配体的一个羧酸氧和一个酚氧占据。生物试验结果表明，1和2对大肠杆菌具有良好的体外抑菌活性。
Synthesis, characterization and antibacterial activity of cyclohexyltin N-(salicylidene)valinates
Abstract : Two new cyclohexyltin N- (salicylidene)valinates, [2-HOC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 3 ( 1 ) and [2-OC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 2 ( 2 ) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and 1 H NMR. The crystal structure of 2 has been determined by X-ray single crystal diffraction. In the complexes, the carboxylate is monodentate. Complex 1 is a four-coordinated tin compound, and 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli .
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