持续的病毒学反应是预防丙型肝炎病毒阳性患者治愈后肝细胞癌复发最有效的方法:一项使用决策树分析的研究

K. Imai, Koji Takai, Shinji Unome, Takao Miwa, Toshihide Maeda, T. Hanai, Y. Shirakami, A. Suetsugu, M. Shimizu
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引用次数: 0

摘要

本研究通过对111例已治愈的丙型肝炎病毒(HCV)阳性患者的决策树分析,评估了影响初始HCC治疗的肝细胞癌(HCC)复发的因素。采用决策树分析将入组患者分为3组:治疗后达到持续病毒学应答(SVR)的患者为1组(n = 33),未达到持续病毒学应答且甲胎蛋白(AFP)水平< 11 ng/mL的患者为2组(n = 30),未达到持续病毒学应答且甲胎蛋白(AFP)水平≥11 ng/mL的患者为3组(n = 48)。Kaplan-Meier法显示,1组患者的无复发生存期明显长于2组和3组(p = 0.004)。此外,直接作用抗病毒药物和干扰素治疗达到SVR的患者之间无显著差异(p = 0.251)。3组无复发生存率明显低于2组(p < 0.001)。Cox比例风险模型显示,SVR是HCC低复发率的唯一独立因素(p = 0.005)。综上所述,达到SVR的患者HCC复发的可能性最小,而未达到SVR且AFP水平≥11 ng/mL的患者HCC复发的可能性最大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sustained Virological Response Is the Most Effective in Preventing Hepatocellular Carcinoma Recurrence after Curative Treatment in Hepatitis C Virus-Positive Patients: A Study Using Decision Tree Analysis
This study evaluated the factors that affect the recurrence of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV)-positive patients, who had received curative treatment for initial HCC, using decision tree analysis in 111 curative cases. The enrolled patients were divided into three groups by the decision tree analysis as follows: Patients who achieved sustained virological response (SVR) after curative treatment belonged to Group 1 (n = 33), those who did not achieve SVR and with alpha-fetoprotein (AFP) levels < 11 ng/mL belonged to Group 2 (n = 30), and those who did not achieve SVR and with AFP levels ≥ 11 ng/mL belonged to Group 3 (n = 48). The Kaplan–Meier method revealed that Group 1 had significantly longer recurrence-free survival than Group 2 or 3 (p = 0.004). Moreover, there was no significant difference between patients achieving SVR with direct-acting antivirals and interferon therapy (p = 0.251). Group 3 had significantly poorer recurrence-free survival than Group 2 (p < 0.001). The Cox proportional hazards model demonstrated that SVR achievement was the only independent factor associated with low HCC recurrence (p = 0.005). In conclusion, patients who achieved SVR were the least prone to HCC recurrence, whereas those who did not achieve SVR and had AFP levels ≥ 11 ng/mL were the most prone to HCC recurrence.
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来源期刊
Journal of International Translational Medicine
Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
0.00%
发文量
317
审稿时长
8 weeks
期刊介绍: Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.
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