{"title":"腺苷激酶的表达调节髓磷脂蛋白的表达","authors":"N. Wu, D. Boison","doi":"10.2174/1874082000701010015","DOIUrl":null,"url":null,"abstract":"Adenosine is known to regulate myelination in vitro. Here we tested the hypothesis that adenosine, regulated by adenosine kinase (ADK), might regulate myelin-specific protein expression and myelination in vivo. We demonstrate that transgenic overexpression of ADK, which reduces adenosine in mouse brain, results in increased levels of myelin prote- olipid protein.","PeriodicalId":88753,"journal":{"name":"The open neuroscience journal","volume":"34 1","pages":"15-19"},"PeriodicalIF":0.0000,"publicationDate":"2007-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Adenosine Kinase Expression Modulates Expression of Myelin Proteolipid Protein\",\"authors\":\"N. Wu, D. Boison\",\"doi\":\"10.2174/1874082000701010015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Adenosine is known to regulate myelination in vitro. Here we tested the hypothesis that adenosine, regulated by adenosine kinase (ADK), might regulate myelin-specific protein expression and myelination in vivo. We demonstrate that transgenic overexpression of ADK, which reduces adenosine in mouse brain, results in increased levels of myelin prote- olipid protein.\",\"PeriodicalId\":88753,\"journal\":{\"name\":\"The open neuroscience journal\",\"volume\":\"34 1\",\"pages\":\"15-19\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-12-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open neuroscience journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874082000701010015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open neuroscience journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874082000701010015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Adenosine Kinase Expression Modulates Expression of Myelin Proteolipid Protein
Adenosine is known to regulate myelination in vitro. Here we tested the hypothesis that adenosine, regulated by adenosine kinase (ADK), might regulate myelin-specific protein expression and myelination in vivo. We demonstrate that transgenic overexpression of ADK, which reduces adenosine in mouse brain, results in increased levels of myelin prote- olipid protein.
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