Origination Progress and Utility of Selective Estrogen Receptor Modulators in Clinical Practice as an Efficient Substitute of Estrogen for Treating Hormone Dependent Issues

The discovery, development and utility of selective estrogen receptor modulators (SERMs) are presented in this study. As per literature review SERMs used in the treatment of estrogen hormone responsive diseases like osteoporosis, Alzheimer, angiogenesis, hyperlipidemia, coronary heart disease, atherosclerosis, endometriosis, breast cancer, post-menopausal depression, dysfunctional uterine bleeding, gynacomastia, Albright syndrome, ovarian cancer, dyspareunia, cyclical mastalgia, hypogondism and induced ovulation in sub-fertile woman, etc. Basically world wide a large no. compounds available those function as SERMs successfully or under different phase clinical trials or discontinued because of unwanted side effects during clinical trials. This work describes the specific reference compounds which have created a substitute of estrogen for treating hormone dependent issues.