糖皮质激素在急性淋巴细胞白血病治疗中的抗白血病作用

Pediatric pharmacology Pub Date : 2023-08-22 DOI:10.15690/pf.v20i4.2603

M. Shervashidze, D. S. Smirnova, T. T. Valiev, K. Kirgizov, S. Varfolomeeva

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引用次数: 0

摘要

糖皮质激素(Glucocorticoids, GC)由于具有抑制细胞周期和诱导细胞凋亡的作用，被用作抗炎、免疫抑制和抗肿瘤药物已有几十年的历史，但其作用机制尚不完全清楚。糖皮质激素在急性淋巴细胞白血病的治疗中发挥着关键作用，在诱导和再诱导阶段处于最前沿。肿瘤克隆对胃癌的反应决定了胃癌的危险人群和预后。本文将介绍一些抗白血病作用的机制和耐药因素。

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Antileukemic impact of glucocorticoid use in acute lymphoblastic leukaemia treatment

Glucocorticoids (GC) are used as anti-inflammatory, immunosupressive and anti-tumor agents for several decades due to their ability to cell cycle inhibition and apoptosis induction but mechanism of action is not fully explored. Glucocorticoids play one of the key roles in acute lymphoblastic leukaemia treatment and are at the forefront in induction and reinduction phases. The response of tumor clone to GC determines a risk group and prognosis. A number of mechanisms of antileukemic action and resistance factors will be describe in this article.

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Pediatric pharmacology

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