在 nivolumab 相关大疱性丘疹中检测 BP180 NC16a 和 C 端域以及 LAD-1 的 IgG 抗体。

IF 2 4区地球科学 Q3 GEOSCIENCES, MULTIDISCIPLINARY

Comptes Rendus Geoscience Pub Date : 2019-10-01 DOI:10.1684/ejd.2019.3618

Yu Matsui, Teruhiko Makino, Norito Ishii, Takashi Hashimoto, Tadamichi Shimizu

引用次数: 3

摘要

在非bp患者中，抗pd1 /PD-L1治疗期间产生多种自身抗体也有报道。例如，在一例由派姆单抗引起的类似扁平地衣的皮疹中，检测到抗桥粒蛋白1、2和桥粒蛋白1、3的抗体[6]。同样，在一例尼伏单抗诱导的地衣样皮炎患者中检测到抗bp180抗体[3]。此外，一名BP患者在纳武单抗治疗期间产生了BP180和desmoglein 3的自身抗体[7]。然而，在本例患者中所见的针对BP180不同表位的自身抗体的产生从未被证实。众所周知，pd -1缺陷小鼠会产生自身免疫，pd -1缺陷被认为会干扰生发中心B细胞的选择，最终导致自身反应性B细胞和T细胞的扩增以及自身抗体的产生[8]。虽然一个单独的案例不足以得出明确的结论，但我们的案例为这一假设提供了进一步的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Detection of IgG antibodies to BP180 NC16a and C-terminal domains and LAD-1 in nivolumab-associated bullous pemphigoid.

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来源期刊

Comptes Rendus Geoscience 地学-地球科学综合

CiteScore

2.80

自引率

14.30%

发文量

审稿时长

5.9 weeks

期刊介绍： Created in 1835 by physicist François Arago, then Permanent Secretary, the journal Comptes Rendus de l''Académie des sciences allows researchers to quickly make their work known to the international scientific community. It is divided into seven titles covering the range of scientific research fields: Mathematics, Mechanics, Chemistry, Biology, Geoscience, Physics and Palevol. Each series is led by an editor-in-chief assisted by an editorial committee. Submitted articles are reviewed by two scientists with recognized competence in the field concerned. They can be notes, announcing significant new results, as well as review articles, allowing for a fine-tuning, or even proceedings of symposia and other thematic issues, under the direction of invited editors, French or foreign.