丙酸睾酮促进趾长伸肌移植血管生成和神经再生

A. Javed, J. Qazi
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引用次数: 2

摘要

雄激素以改善骨骼肌再生过程而闻名。它们是快速神经再生和肌肉移植血管生成的有效药物。到目前为止,已有几项研究报道了它们在临床移植中的合成代谢作用。在本研究中,研究了丙酸睾酮(TP)对指外长肌移植的影响。我们注意到,在第2周,补充TP显著增加了血管和神经的直径以及它们的壁厚。然后,上述模式逐渐减少,直到第4周激素供应结束。结果表明,剂量过大会对EDL肌肉移植再生过程产生负面影响,导致神经和血管供应萎缩。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Testosterone Propionate Promotes Angiogenesis and Nerve Regeneration in Extensor Digitorrum Longus Muscle Grafts
Androgens are renowned for improving the process of skeletal muscle regeneration. They are potent agents for quick reinnervation of nerves and angiogenesis in muscle grafts. So far several studies have reported their anabolic roles in clinical transplantations. In the current study, effects of testosterone propionate (TP) onextensordigitorrumlongus muscle grafts were studied. It was noticed that TP supplementation caused significant increase in blood vessels and nerves diameter along with their walls thickness up to 2nd week. Then there was a gradual decrease observed in the above mentioned pattern till end of 4thweek of the hormone supply. It was found that over dosage caused negative effects on the process of regeneration in EDL muscle grafts and resulted in shrinkage of nerves and vascular supply.
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