DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine

The binding interactions of cis-[Pd(sac)2(PPh2Et)2] with DNA and HSA were comprehensively studied by a number of experimental methods and molecular docking studies. The Pd(II) complex bound to AT-rich sites in the major groove of DNA, and interacted with the hydrophobic cavity of the subdomain IIA of HSA. These experimental findings were supported by molecular docking studies. The Pd(II) complex had shown strong cytotoxic activity against different cancer cell lines and it also had selectivity especially for MCF-7 breast cancer cells higher than cisplatin.