Current trends in oral cancer: A systematic review

Oral cancer remains one of the most common and challenging malignancies of the head and neck region. Articles were retrieved from Pubmed using specific keywords. Recent data showed that the incidence and mortality have increased over the last decades.  It has poor prognosis and ranks among all cancer mortality. Tobacco smoking, alcohol, betel quid and areca nut chewing have been associated with a higher risk for oral cancers. This review summarizes the incidence, prevalence and mortality rates associated with oral cancer. We also investigated the strategies for early diagnosis, the molecular pathway of carcinogenesis, and the current treatment modalities available for oral cancer.