含紫外光和荧光化合物的寡核苷酸缀合物的合成

Margarita Alvira, S. Quinn, A. Aviñó, D. Fitzmaurice, R. Eritja
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引用次数: 2

摘要

介绍了携带紫素和荧光素的寡核苷酸偶联物的制备。适当的羧基衍生物与携带脂肪族氨基的寡核苷酸反应得到所需的化合物。本文报道了在寡核苷酸5′端引入氨基的一种简单方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of oligonucleotide conjugates carrying viologen and fluorescent compounds
The preparation of oligonucleotide conjugates carrying viologen and fluorescein is described. Reaction of the appropriate carboxyl derivatives with oligonucleotides carrying aliphatic amino groups gave the desired compounds. A simple method for the introduction of the amino group at the 5'-end of the oligonucleotides is reported.
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