DNA甲基化与肺纤维化的诊断和治疗进展

Q4 Health Professions

中华检验医学杂志 Pub Date : 2020-01-11 DOI:10.3760/CMA.J.ISSN.1009-9158.2020.01.011

Z. Xiang

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引用次数: 0

摘要

肺纤维化是许多肺部疾病的晚期。它是一种细胞外基质过度沉积、组织瘢痕形成和肺组织重塑的病理过程。近年来，DNA甲基化已被证实与器官纤维化有关，包括肺、肝、肾纤维化等。DNA甲基化在临床诊断和治疗中起着重要作用。本文综述了DNA甲基化在肺纤维化发生发展中的作用，并对肺纤维化的发病机制和新的抗纤维化策略进行了探讨。关键词:DNA甲基化;肺纤维化;表观遗传学

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Progress in diagnosis and treatment of DNA methylation and pulmonary fibrosis

Pulmonary fibrosis is the late stage of many lung diseases. It′s a pathological process with excessive deposition of extracellular matrix, tissue scar formation and lung tissue remodeling. Recently, DNA methylation has been demonstrated to involve in organ fibrosis, includingpulmonary, liver, renal fibrosis and so on. DNA methylation plays an important role in clinical diagnosis and treatment. This article reviews the role of DNA methylation in the development of pulmonary fibrosis and discusses thepathogenic mechanism of pulmonary fibrosis and new anti-fibrotic strategy. Key words: DNA methylation; Pulmonary fibrosis; Epigenetics

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来源期刊

中华检验医学杂志 Health Professions-Medical Laboratory Technology

CiteScore

0.40

自引率

0.00%

发文量

8037

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