{"title":"牙周组织干细胞和间充质干细胞","authors":"Tomoaki Iwayama , Hiromi Sakashita , Masahide Takedachi , Shinya Murakami","doi":"10.1016/j.jdsr.2022.04.001","DOIUrl":null,"url":null,"abstract":"<div><p>Periodontal tissue stem cells, which play a crucial role in maintaining the homeostasis of periodontal tissues, are found in the periodontal ligament (PDL). These cells have long been referred to as mesenchymal stem/stromal cells (MSCs), and their clinical applications have been extensively studied. However, tissue stem cells in the PDL have not been thoroughly investigated, and they may be different from MSCs. Recent advances in stem cell biology, such as genetic lineage tracing, identification of label-retaining cells, and single-cell transcriptome analysis, have made it possible to analyze tissue stem cells in the PDL <em>in vivo</em>. In this review, we summarize recent findings on these stem cell populations in PDL and discuss future research directions toward developing periodontal regenerative therapy.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 172-178"},"PeriodicalIF":5.7000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761622000096/pdfft?md5=b7578ca8fbe41d9989dce1400d295b37&pid=1-s2.0-S1882761622000096-main.pdf","citationCount":"7","resultStr":"{\"title\":\"Periodontal tissue stem cells and mesenchymal stem cells in the periodontal ligament\",\"authors\":\"Tomoaki Iwayama , Hiromi Sakashita , Masahide Takedachi , Shinya Murakami\",\"doi\":\"10.1016/j.jdsr.2022.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Periodontal tissue stem cells, which play a crucial role in maintaining the homeostasis of periodontal tissues, are found in the periodontal ligament (PDL). These cells have long been referred to as mesenchymal stem/stromal cells (MSCs), and their clinical applications have been extensively studied. However, tissue stem cells in the PDL have not been thoroughly investigated, and they may be different from MSCs. Recent advances in stem cell biology, such as genetic lineage tracing, identification of label-retaining cells, and single-cell transcriptome analysis, have made it possible to analyze tissue stem cells in the PDL <em>in vivo</em>. In this review, we summarize recent findings on these stem cell populations in PDL and discuss future research directions toward developing periodontal regenerative therapy.</p></div>\",\"PeriodicalId\":51334,\"journal\":{\"name\":\"Japanese Dental Science Review\",\"volume\":\"58 \",\"pages\":\"Pages 172-178\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2022-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1882761622000096/pdfft?md5=b7578ca8fbe41d9989dce1400d295b37&pid=1-s2.0-S1882761622000096-main.pdf\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese Dental Science Review\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1882761622000096\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Dental Science Review","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1882761622000096","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Periodontal tissue stem cells and mesenchymal stem cells in the periodontal ligament
Periodontal tissue stem cells, which play a crucial role in maintaining the homeostasis of periodontal tissues, are found in the periodontal ligament (PDL). These cells have long been referred to as mesenchymal stem/stromal cells (MSCs), and their clinical applications have been extensively studied. However, tissue stem cells in the PDL have not been thoroughly investigated, and they may be different from MSCs. Recent advances in stem cell biology, such as genetic lineage tracing, identification of label-retaining cells, and single-cell transcriptome analysis, have made it possible to analyze tissue stem cells in the PDL in vivo. In this review, we summarize recent findings on these stem cell populations in PDL and discuss future research directions toward developing periodontal regenerative therapy.
期刊介绍：
The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
