{"title":"(Tn抗原)。","authors":"H. Nakada","doi":"10.32388/nxgt9h","DOIUrl":null,"url":null,"abstract":"A protein antigen that is comprised of the monosaccharide N-acetylgalactosamine (GalNAc) bound to serine or threonine by O-linked glycosylation. Aberrant expression of Tn antigen by all blood cell lineages is associated with a rare hematological disorder called Tn-syndrome. Increased expression of this monosaccharide modification is also associated with some cancers and this antigen is being investigated for use as either a biomarker or therapeutic target for these associated malignancies.","PeriodicalId":22197,"journal":{"name":"Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme","volume":"13 1","pages":"1858-62"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"[Tn antigen].\",\"authors\":\"H. Nakada\",\"doi\":\"10.32388/nxgt9h\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A protein antigen that is comprised of the monosaccharide N-acetylgalactosamine (GalNAc) bound to serine or threonine by O-linked glycosylation. Aberrant expression of Tn antigen by all blood cell lineages is associated with a rare hematological disorder called Tn-syndrome. Increased expression of this monosaccharide modification is also associated with some cancers and this antigen is being investigated for use as either a biomarker or therapeutic target for these associated malignancies.\",\"PeriodicalId\":22197,\"journal\":{\"name\":\"Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\",\"volume\":\"13 1\",\"pages\":\"1858-62\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32388/nxgt9h\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32388/nxgt9h","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A protein antigen that is comprised of the monosaccharide N-acetylgalactosamine (GalNAc) bound to serine or threonine by O-linked glycosylation. Aberrant expression of Tn antigen by all blood cell lineages is associated with a rare hematological disorder called Tn-syndrome. Increased expression of this monosaccharide modification is also associated with some cancers and this antigen is being investigated for use as either a biomarker or therapeutic target for these associated malignancies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
