人工智能(视觉和视觉学习)是否可能成为替代动物的解决方案:基于学习的毒性背诵?

R. Mishra, R. Kaushik, Ajay Shukla, Smriti Ojha, Sudhanshu Mishra, R. S. Dubey
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摘要

与动物和人类研究类似,数据表明,当许多动物模型外推到人类身上时,预测药物效果的可靠性是有限的。这导致了时间和金钱的不平衡浪费和药物开发过程中的噩梦,因为药物在动物或临床前模型中效果良好,因此在临床研究或临床试验中失败,反之亦然。在这种技术中,机器学习和深度学习(M和D)是人工智能的一个子集。我们希望这将消除长时间搜索的需要,减少策略中牺牲的动物数量,并减少测试所需的成本和时间。我们认识到,在毒理学或临床前研究和测试中完全替代动物仍然是一个挑战——我们承认,基于M和D学习的动物毒性预测可能是关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IS ARTIFICIAL INTELLIGENCE VIZ M AND D LEARNING COULD BE THE SOLUTION PROMISING ALTERNATIVE TO ANIMALS: A LEARNING-BASED TOXICITY RECITATION?
Similar to animal and human studies, the data show that when many animal models are extrapolated to humans, reliability is limited when it comes to predicting drug effects. This leads to an unbalanced waste of time and money and nightmares during drug development because the drug works well in animals or pre-clinical models and therefore fails in clinical studies or clinical trials, or vice versa. In this technique, machine and deep learning (M and D) is a subset of artificial intelligence. We hope this will eliminate the need for lengthy searches, reduce the number of animals sacrificed in the strategy, and reduce the cost and time required for testing. We recognize that full replacement of animals in toxicological or pre-clinical studies and tests remains a challenge - we acknowledge M and D learning-based animal toxicity prediction can be the key.
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