一种治疗口腔阿弗特溃疡的新型多药黏合剂配方

R. Sahu, D. Jain, R. Mehani, Hemani, L. Hingorani, V. Thawani
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引用次数: 1

摘要

背景:口腔溃疡是最常见的引起不适的病变,患者寻求治疗以减轻疼痛和促进早期愈合。现代医学和阿育吠陀的各种治疗方式以药膏和漱口水的形式使用,效果各异。消炎药、酶制剂、丙种球蛋白和免疫抑制剂已被使用。方法:选用甘草、儿茶、石榴、姜黄、薄荷五种草药提取物制备黏附凝胶,用于治疗各种病因的口腔溃疡。凝胶在印度Pharmanza Herbals ptt . Ltd.采用Schmolka冷法制备。采用不同浓度的活性药物成分(API)提取物制备了5种配方。结果:对制剂的理化性质进行了分析。对5种配方进行了初步试验。F5配方由于其较高的聚合物含量而具有最佳粘度;它能够在黏液表面停留足够长的时间以释放其API效应。F1配方均匀、美观、稳定性好,粘度和凝胶强度可接受,是治疗口腔阿弗顿溃疡的理想配方。结论:基于甘草、儿茶、石榴、姜黄和薄荷的镇痛、抗炎、抗氧化、伤口愈合、抗菌和局部麻醉等特性,本研究结果有力地证明了含甘草、儿茶、石榴、薄荷提取物的多药凝胶可作为一种有效、安全的治疗阿佛脱溃疡的替代药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel poly herbal muco-adhesive formulation for treatment of oral aphthous ulcer
Background: Oral ulcers are the most frequent lesions that cause discomfort for which the patients seek treatment for alleviating pain and facilitate early healing. Various treatment modalities from modern medicine and Ayurveda are used in the form of ointments and mouthwashes with varying efficacy. Anti-inflammatory medicines, enzymatic preparations, gamma globulins and immune suppressants have been used.Methods: Extracts of five chosen herbs, Glycyrrhiza glabra, Acacia catechu, Punica Granatum, Curcuma longa and Mentha piperita were used for preparing mucoadhesive gel for the treatment of oral aphthous ulcers of any etiology. Gel was prepared by cold method of Schmolka at M/s Pharmanza Herbals Pvt. Ltd., India. Five formulations were prepared with using different concentration of active pharmaceutical ingredient (API) extracts.Results: Formulations were analyzed for different physical and chemical properties. Preliminary trial was done with five formulations. The F5 formulation has the premier viscosity because of its higher polymer content; it is able to remain on mucous surface long enough to release its API effect. Since the uniformity, proper appearance, stability and acceptable viscosity and gel strength the F1 formulation was selected as the superior formulation which could prove ideal for treatment of oral aphthous ulcers.Conclusions: The results provide strong evidence that polyherbal gel containing extracts of Glycyrrhiza glabra, Acacia catechu, Punica granatum, Curcuma longa and Mentha piperita on the basis of their analgesic, anti-inflammatory, antioxidant, wound healing, antimicrobial and local anesthetic properties can be used as an effective and safe alternative for the management of aphthous ulcers.
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