女性尿道壁淋巴样结节结构的宏观显微镜特征

N. Alexeeva, O. T. Devonaev, S. Klochkova, D. A. Sokolov, D. Nikityuk
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引用次数: 0

摘要

本研究旨在探讨女性尿道淋巴样结节的结构及定量指标的宏观显微特征。材料和方法。采用Harris苏木精选择性染色,采用MBS-9型双目立体显微镜对63例不同年龄组女性尸体尿道壁淋巴样结节的形貌、数量和大小进行了观察。将材料固定在10%的福尔马林溶液中。在ImageJ程序中拍照并测量淋巴样结节的面积。统计数据处理采用基于Statistica 6.0程序的参数统计方法。统计数据处理包括算术平均值的计算及其误差,以及各指标变异序列的幅度分析。儿童早期尿道淋巴结节数量最多,这与生命最初几年淋巴样细胞总数最多、淋巴样组织严重程度最高的观念相对应。淋巴样结节密度在儿童期第一阶段最大(9,5 - 10,5个结节),随后依次降低。与儿童期1期相比,老年期尿道上1 / 3壁淋巴结节定位密度降低1.7倍(p<0.05),中下1 / 3壁淋巴结节定位密度降低1.2倍(p<0.05),尿道整体淋巴结节定位密度降低1.3倍(p<0.05)。根据我们的数据,淋巴结节位置密度的变化幅度系列(个体最大值和最小值之间的差异)在出生后的个体发育过程中没有显著变化。出生后个体发育时期淋巴样结节的大小在儿童的第一阶段是最大的。此外,该指标的值在老年和百岁老人中下降并达到最小。研究表明,尿道壁淋巴组织处于形态发育成熟的不同阶段,发现淋巴样结节,众所周知,这被认为是淋巴组织发育功能较成熟的阶段。整个女性尿道淋巴结节的位置密度值在出生后的个体发生过程中变化不大,在老年和长寿期间观察到的数量最少,最大值实际上没有变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Macro-microscopic features of the structure of lymphoid nodules in the wall of the female urethra
The aim of the investigation was to study the macro-microscopic features of the structure and quantitative indicators of the lymphoid nodules of the female urethra in postnatal ontogenesis.Material and methods. The topography, number and size of lymphoid nodules in the urethral wall from corpses of 63 women of different age groups were studied by macro-microscopy using binocular stereomicroscope MBS-9 after elective staining with Harris hematoxylin. The material was fixed in a 10% formalin solution. The preparations were photographed and the area of lymphoid nodules was measured in the ImageJ program. For statistical data processing, parametric statistics methods based on the Statistica 6.0 program were used. Statistical data processing included the calculation of arithmetic averages, their errors, and the analysis of the amplitude of the variation series of each indicator.Results. The maximum number of lymphoid nodules in the urethra in early childhood corresponds to the idea of the largest total number of lymphoid cells, the severity of lymphoid tissue in the first years of life. The density of lymphoid nodules is maximum in the 1st period of childhood (9,5–10,5 nodules), and then decreases sequentially. In senile age, compared with the 1st period of childhood, the density of localization of lymphoid nodules decreases in the walls of the upper third of the urethra by 1.7 times (p< 0.05), the middle and lower thirds of the organ - by 1.2 times (p<0.05) and the urethra as a whole – by 1.3 times (p<0.05). The amplitude of the variation series (differences between individual maximum and minimum) of the density of the location of lymphoid nodules, according to our data, does not change significantly during postnatal ontogenesis. The size of the lymphoid nodule during postnatal ontogenesis is maximal in the 1st period of childhood. Further, the value of this indicator decreases and reaches a minimum in old age and in centenarians.Conclusion. The study showed that lymphoid tissue in the urethral wall is at different stages of morphogenetic maturity, lymphoid nodules are found, which, as is known, are considered to be a more functionally mature stage of lymphoid tissue development. The values of the density of the location of lymphoid nodules throughout the female urethra in postnatal ontogenesis change slightly, the minimum number of them is observed in old age and the period of longevity, the maximum does not actually change.
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