Histopathological Changes and Harmful Effects of Garamycin (60) Mg by Intramuscular Injection in Experimental White Rats

This study has shown the effects of gentamicin sulfate injection (60 mg/kg/b.w.) in thigh muscle for two months twice daily (morning and evening) on the histological structure of the kidneys, liver and cardiac muscle of rats. Vacuolation, dilatated cortical tubules and degeneration, necrosis of proximal convoluted tubules were seen in the treated group. Congestion, cardiac muscle vacuolation as well as hepatocytes degeneration and sinusoids congestion with obvious bile duct proliferation were also seen. Through our studies showed clinical findings such as anorexia and subsequent emaciation and certain animals were presumably killed in the treatment group due to gentamicin caused renal failure.