Efek Pemberian Ekstrak Etanol Buah Pare (Momordica Charantia L.) Terhadap Gambaran Histopatologi Organ Hepar Pada Tikus Putih Jantan Galur Wistar (Rattus Novergicus L.)

Buah Pare (Momordica charantia L.) merupakan buah yang memiliki berbagai khasiat terapetik tapi belum diketahui efek samping apabila dikonsumsi secara berlebihan terhadap gangguan organ hepar. Tujuan penelitian ini untuk Mengetahui Pengaruh Efek Ekstrak Etanol Buah Pare pada Gambaran Histopatologi Organ hepar Tikus putih jantan galur wistar. Sampel diekstraksi menggunakan metode maserasi. Ekstrak yang diperoleh diberikan kepada 4 kelompok hewan uji dengan konsentrasi 0,100,200, dan 400mg/ml secara berturut-turut. Setelah 50 hari, organ hepar hewan uji diambil dan dibuat preparat histopatologi. Gambaran Histopatologi menunjukan sampel organ hepar perlakuan P(100) dosis 100 mg/mL terlihat fokus perlemakan, untuk perlakuan P(200) dosis 200 mg/mL terlihat perlemakan disertai dengan terjadinya nekrosis, juga terlihat munculnya sel regeneratif. Pada P(400) dosis 400 mg/mL munculnya perlemakan, nekrosis, kongesti venacentralis, juga terlihat tanda sel regeneratif. Hal ini menunjukkan bahwa penggunaan ekstrak buah pare dapat menyebabkan efek negative pada jaringan sampel organ hepar galur wistarBitter Melon (Momordica Charantia L) is a fruit that has a various of therapeutic properties. However, Consuming an excess amount af bitter melon may have an unknown side effects towards the human’s liver. The Purpose of this research is to determine the effect of histopathlogical picture of the liver in the male white rats of wistar strain. The sample was extracted by using the maceration method. The acquired extract was given to the four guinea pig with 0, 100, 200, and 400 mg/ml concentration consecutively. After 50 days, the guinea pig’s liver organ was taken to be tested, and histopathological preparations was made. Histopathological picture shows fats that was accumulated in the liver tissue of the liver that were given 100 mg/ml of P(100). For Treatment P(200) dose of 200 mg/ml was seen to be accompanied by fatty necrosis, also seen the appeareance of regenerative cells. At P(400) dose of 400 mg/ml the appearance of fat, necrosis, venacentral Congestion, also seen signs of regenerative cells. This shows that the use of bitter melon extract may cause a side/negative effect to the sampel’s hepatic tissue “galur wistar”