Role of microRNA in atrial fibrillation: What are the implications for gene therapy?

The utilization of targeted genetic abnormalities to personalize AF therapy is a compelling approach in current era of efforts to individualize the best therapeutic option for a certain patient. There are certain advantages and disadvantages in the implementation of gene therapy for AF.10–12 Some advantages comprise the fact that is tissue specific with fewer side effects. Due to the fact that the AF substrate is not homogeneous, the efficacy of a single genetic alteration may decrease, and it may preclude the simplicity of the procedure.