Osmund C. Enechi, Christian E. Odo, Onyedika N. Onyekwelu
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引用次数: 2
摘要
背景与目的在尼日利亚，Alstonia boonei的茎皮在传统医学中用于治疗或减轻炎症和疼痛。鉴于此，本研究探讨了其茎皮乙醇提取物对琼脂诱导的大鼠白细胞迁移的作用及其抗炎机制。方法采用标准分析方法观察木香茎皮乙醇提取物对琼脂诱导大鼠白细胞迁移的影响。结果:结果显示:p <与对照组(生理盐水5 ml/kg b. w)相比，给予400、800和1200 mg/kg体重(b. w)的大鼠对白细胞迁移的抑制作用(0.05)。该提取物的抑制作用呈剂量依赖性，与对照抗炎药吲哚美辛(0.3 mg/kg b. w)的抑制作用相当。结论木犀草茎皮乙醇提取物对白细胞迁移具有显著的抑制作用，证明木犀草茎皮作为抗炎药的传统应用是合理的。
Inhibition of leucocyte migration: A mechanism of anti-inflammatory effect of the ethanol extract of the stem bark of Alstonia boonei in Wistar rats
Background and aim
The stem bark of Alstonia boonei is used in traditional medicine to treat or reduce inflammation and pain in Nigeria. In view of these, the effect of the ethanol extract of its stem bark on agar-induced leucocyte migration in rats as a mechanism of anti-inflammation was investigated.
Methods
The effect of the ethanol extract of the stem bark of A. boonei on agar-induced leucocyte migration in rats was evaluated using standard analytical method.
Results
The results showed significant (p < 0.05) inhibitions of leucocyte migrations in the rats administered 400, 800 and 1200 mg/kg body weight (b. w) compared to the leucocyte migration of the rats in the control group (5 ml/kg b. w of normal saline). The inhibitory effect of the extract was dose-dependent and comparable to that of the reference anti-inflammatory drug, indomethacin (0.3 mg/kg b. w).
Conclusion
The data indicate that the ethanol extract of the stem bark of A. boonei possesses remarkable inhibitory effect on leucocyte migration and therefore, justifies the traditional use of the stem bark of A. boonei as an anti-inflammatory agent.
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