小鼠内肛门括约肌平滑肌细胞中的节律性钙瞬变

Neurogastroenterology & Motility Pub Date : 2020-03-01 DOI:10.1111/nmo.13746

Caroline A Cobine, Karen I. Hannigan, Megan McMahon, Emer Ni Bhraonain, S. Baker, K. Keef

{"title":"小鼠内肛门括约肌平滑肌细胞中的节律性钙瞬变","authors":"Caroline A Cobine, Karen I. Hannigan, Megan McMahon, Emer Ni Bhraonain, S. Baker, K. Keef","doi":"10.1111/nmo.13746","DOIUrl":null,"url":null,"abstract":"The internal anal sphincter (IAS) exhibits slow waves (SWs) and tone that are dependent upon L‐type Ca2+ channels (CavL) suggesting that phasic events (ie, SWs) play a fundamental role in tone generation. The present study further examined phasic activity in the IAS by measuring the spatiotemporal properties of Ca2+ transients (CTs) in IAS smooth muscle cells (SMCs).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"287 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Rhythmic calcium transients in smooth muscle cells of the mouse internal anal sphincter\",\"authors\":\"Caroline A Cobine, Karen I. Hannigan, Megan McMahon, Emer Ni Bhraonain, S. Baker, K. Keef\",\"doi\":\"10.1111/nmo.13746\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The internal anal sphincter (IAS) exhibits slow waves (SWs) and tone that are dependent upon L‐type Ca2+ channels (CavL) suggesting that phasic events (ie, SWs) play a fundamental role in tone generation. The present study further examined phasic activity in the IAS by measuring the spatiotemporal properties of Ca2+ transients (CTs) in IAS smooth muscle cells (SMCs).\",\"PeriodicalId\":19104,\"journal\":{\"name\":\"Neurogastroenterology & Motility\",\"volume\":\"287 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurogastroenterology & Motility\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/nmo.13746\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurogastroenterology & Motility","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/nmo.13746","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 5

摘要

内肛门括约肌(IAS)表现出依赖于L型Ca2+通道(CavL)的慢波(SWs)和张力，这表明相位事件(即SWs)在张力产生中起着基本作用。本研究通过测量IAS平滑肌细胞(SMCs)中Ca2+瞬态(CTs)的时空特性，进一步研究了IAS的相活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Rhythmic calcium transients in smooth muscle cells of the mouse internal anal sphincter

The internal anal sphincter (IAS) exhibits slow waves (SWs) and tone that are dependent upon L‐type Ca2+ channels (CavL) suggesting that phasic events (ie, SWs) play a fundamental role in tone generation. The present study further examined phasic activity in the IAS by measuring the spatiotemporal properties of Ca2+ transients (CTs) in IAS smooth muscle cells (SMCs).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neurogastroenterology & Motility

自引率

0.00%

发文量