香芹酮通过抑制脂多糖诱导的小鼠急性肺损伤NF-KB通路发挥肺抗炎作用

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) Pub Date : 2023-06-16 DOI:10.31351/vol32iss1pp125-132

Samah Mahde, Sarmad Haishm

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引用次数: 0

摘要

背景:急性肺损伤(ALI)是最严重的疾病之一，其特征是持续肺部感染导致炎症反应加剧。香芹酮是一种手性单萜类酮，存在于莳萝、香菜和绿薄荷的精油中。它具有抗氧化、抗炎和抗菌等作用。本研究探讨了香芹酮对脂多糖(LPS)诱导的ALI的抗炎保护作用及可能的作用机制。

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Carvone exerts lung anti-inflammatory effect through hampering NF-KB pathway in lipopolysaccharide-induced acute lung injury in mice

Background: Acute lung injury (ALI) is among the most serious conditions characterized by an exacerbation of inflammatory response that can result from a persistent lung infection. Carvone is chiral monoterpenoid ketone present in the essential oils of dill, caraway, and spearmint. It shows antioxidant, anti-inflammatory, and antimicrobial effects among others. In this study, the lung anti-inflammatory and protective effects and potential mechanism of action of carvone were investigated in ALI induced by Lipopolysaccharide (LPS).

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Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)

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