{"title":"碳-碳与胺和铵盐的烷基化反应","authors":"J. Brewster, E. Eliel","doi":"10.1002/0471264180.OR007.03","DOIUrl":null,"url":null,"abstract":"This chapter is a review of those reactions of compounds containing labile amino groups in which a carbon-carbon bond is formed by amine replacement as, for example, in the alkylation of diethyl malonate by 1-dimethylamino-3-butanone. Attention has been given primarily to reactions of amines prepared by the Mannich reaction (Mannich bases), but for comparison, analogous reactions of simpler quaternary ammonium salts have been included. \n \n \nKeywords: \n \ncarbon-carbon alkylations; \namines; \nammonium salts; \ncyanide; \nreplacements; \nactive methyl groups; \nactive methylene groups; \nindole; \nquaternary salts; \norganometallic compounds; \nrelated reactions; \nexperimental conditions","PeriodicalId":19539,"journal":{"name":"Organic Reactions","volume":"916 1","pages":"99-197"},"PeriodicalIF":0.0000,"publicationDate":"2011-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Carbon-Carbon Alkylations with Amines and Ammonium Salts\",\"authors\":\"J. Brewster, E. Eliel\",\"doi\":\"10.1002/0471264180.OR007.03\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This chapter is a review of those reactions of compounds containing labile amino groups in which a carbon-carbon bond is formed by amine replacement as, for example, in the alkylation of diethyl malonate by 1-dimethylamino-3-butanone. Attention has been given primarily to reactions of amines prepared by the Mannich reaction (Mannich bases), but for comparison, analogous reactions of simpler quaternary ammonium salts have been included. \\n \\n \\nKeywords: \\n \\ncarbon-carbon alkylations; \\namines; \\nammonium salts; \\ncyanide; \\nreplacements; \\nactive methyl groups; \\nactive methylene groups; \\nindole; \\nquaternary salts; \\norganometallic compounds; \\nrelated reactions; \\nexperimental conditions\",\"PeriodicalId\":19539,\"journal\":{\"name\":\"Organic Reactions\",\"volume\":\"916 1\",\"pages\":\"99-197\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Reactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/0471264180.OR007.03\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Reactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/0471264180.OR007.03","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Carbon-Carbon Alkylations with Amines and Ammonium Salts
This chapter is a review of those reactions of compounds containing labile amino groups in which a carbon-carbon bond is formed by amine replacement as, for example, in the alkylation of diethyl malonate by 1-dimethylamino-3-butanone. Attention has been given primarily to reactions of amines prepared by the Mannich reaction (Mannich bases), but for comparison, analogous reactions of simpler quaternary ammonium salts have been included.
Keywords:
carbon-carbon alkylations;
amines;
ammonium salts;
cyanide;
replacements;
active methyl groups;
active methylene groups;
indole;
quaternary salts;
organometallic compounds;
related reactions;
experimental conditions
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